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• Mean activities

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• Activity deltas table
• Regulatory interactions
• Motifs sorted by significance (text)
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Motif ID: POU5F1_SOX2{dimer}.p2

Z-value: 2.171

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Top targets:

Promoter	Score	Refseq	Gene Symbol	Gene Name
chr4_+_74493918	11.662		ALB	albumin
chr4_+_74493174	10.931		ALB	albumin
chr4_+_74493331	9.295		ALB	albumin
chr2_-_215949566	8.821		FN1	fibronectin 1
chr4_+_74493266	8.808		ALB	albumin
chr10_+_7785235	8.096	NM_002216	ITIH2	inter-alpha (globulin) inhibitor H2
chr10_+_7785331	7.940		ITIH2	inter-alpha (globulin) inhibitor H2
chr4_+_74493218	7.870		ALB	albumin
chr10_+_7785360	7.796		ITIH2	inter-alpha (globulin) inhibitor H2
chr10_+_7785290	7.622		ITIH2	inter-alpha (globulin) inhibitor H2
chr17_+_24394281	7.344		PIPOX	pipecolic acid oxidase
chr4_+_100714995	6.744		MTTP	microsomal triglyceride transfer protein
chr17_+_24394043	6.035	NM_016518	PIPOX	pipecolic acid oxidase
chr16_-_54424517	5.217	NM_001025194 NM_001025195 NM_001266	CES1	carboxylesterase 1
chr12_-_9123126	5.156		A2M	alpha-2-macroglobulin
chr4_+_74493301	5.014		ALB	albumin
chr7_+_45899080	4.221		IGFBP1	insulin-like growth factor binding protein 1
chr10_+_4995685	4.077		AKR1C1	aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase)
chr8_-_17797127	4.069	NM_147203 NM_201553 NM_004467 NM_201552	FGL1	fibrinogen-like 1
chr7_+_45899621	3.974
chr10_-_5035967	3.754	NM_001135241	AKR1C1 AKR1C2	aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase) aldo-keto reductase family 1, member C2 (dihydrodiol dehydrogenase 2; bile acid binding protein; 3-alpha hydroxysteroid dehydrogenase, type III)
chr4_-_187881977	3.674	NM_005245	FAT1	FAT tumor suppressor homolog 1 (Drosophila)
chr4_+_74500748	3.596		ALB	albumin
chr4_-_110942783	3.422	NM_000204	CFI	complement factor I
chr16_+_70646008	3.375	NM_001126102 NM_005143	HP	haptoglobin
chr13_+_96592051	3.183		MBNL2	muscleblind-like 2 (Drosophila)
chr10_+_4995597	3.158		AKR1C1 AKR1C3	aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase) aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II)
chr13_-_47885018	3.050		LPAR6	lysophosphatidic acid receptor 6
chr10_-_52315436	3.047	NM_001198818 NM_001198819 NM_001198820 NM_014576 NM_138932 NM_138933	A1CF	APOBEC1 complementation factor
chr10_+_4995453	2.935	NM_001353	AKR1C1	aldo-keto reductase family 1, member C1 (dihydrodiol dehydrogenase 1; 20-alpha (3-alpha)-hydroxysteroid dehydrogenase)
chr2_-_21079145	2.719		APOB	apolipoprotein B (including Ag(x) antigen)
chr19_-_53081326	2.684		SULT2A1	sulfotransferase family, cytosolic, 2A, dehydroepiandrosterone (DHEA)-preferring, member 1
chr2_+_138438277	2.613	NM_001024074 NM_001024075 NM_006895	HNMT	histamine N-methyltransferase
chr10_+_7785347	2.532		ITIH2	inter-alpha (globulin) inhibitor H2
chr7_+_94130752	2.523		PEG10	paternally expressed 10
chr11_+_69165119	2.451		CCND1	cyclin D1
chr11_+_69165018	2.338	NM_053056	CCND1	cyclin D1
chr9_-_74757735	2.274	NM_000689	ALDH1A1	aldehyde dehydrogenase 1 family, member A1
chrX_-_100920493	2.170		GK	glycerol kinase
chr10_+_114123765	2.161		ACSL5	acyl-CoA synthetase long-chain family member 5
chr7_+_94130673	2.101		PEG10	paternally expressed 10
chr18_-_3001944	2.022	NM_014646	LPIN2	lipin 2
chr7_+_29486010	2.020	NM_001039936	CHN2	chimerin (chimaerin) 2
chr3_-_150422474	1.948	NM_000096	CP	ceruloplasmin (ferroxidase)
chr10_+_124141808	1.779	NM_021622	PLEKHA1	pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1
chr10_-_69267774	1.742	NM_021800 NM_201262	DNAJC12	DnaJ (Hsp40) homolog, subfamily C, member 12
chr12_-_121753795	1.702	NM_177551	GPR109A	G protein-coupled receptor 109A
chr15_+_22652790	1.598	NM_022805	SNRPN	small nuclear ribonucleoprotein polypeptide N
chr15_+_22619886	1.521	NM_022806 NM_022807 NM_022808	SNRPN	small nuclear ribonucleoprotein polypeptide N
chr2_-_188127430	1.513	NM_001032281 NM_006287	TFPI	tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
chr1_+_165564904	1.508	NM_001198783	POU2F1	POU class 2 homeobox 1
chr10_+_114123828	1.489	NM_203379	ACSL5	acyl-CoA synthetase long-chain family member 5
chr4_+_140806536	1.478		MGST2	microsomal glutathione S-transferase 2
chr6_-_138862273	1.455
chr9_-_115877104	1.389		AMBP	alpha-1-microglobulin/bikunin precursor
chr10_+_123744131	1.380		TACC2	transforming, acidic coiled-coil containing protein 2
chr12_-_121767272	1.364	NM_006018	GPR109B	G protein-coupled receptor 109B
chr4_+_74520796	1.356	NM_001134	AFP	alpha-fetoprotein
chr2_+_228386800	1.327	NM_001130046 NM_004591	CCL20	chemokine (C-C motif) ligand 20
chr18_+_27425727	1.311	NM_000371	TTR	transthyretin
chr21_+_39117064	1.261		ETS2	v-ets erythroblastosis virus E26 oncogene homolog 2 (avian)
chr4_+_140806371	1.243	NM_002413	MGST2	microsomal glutathione S-transferase 2
chr5_-_95184121	1.243		GLRX	glutaredoxin (thioltransferase)
chr1_-_41398126	1.195	NM_001172222	SCMH1	sex comb on midleg homolog 1 (Drosophila)
chr2_+_128644510	1.153		UGGT1	UDP-glucose glycoprotein glucosyltransferase 1
chr4_-_155731288	1.135	NM_000508 NM_021871	FGA	fibrinogen alpha chain
chr2_+_113601608	1.079	NM_173842	IL1RN	interleukin 1 receptor antagonist
chr5_-_95184221	1.076	NM_001118890 NM_002064	GLRX	glutaredoxin (thioltransferase)
chr15_+_22772545	1.072		SNRPN	small nuclear ribonucleoprotein polypeptide N
chr2_+_113601616	1.051		IL1RN	interleukin 1 receptor antagonist
chr3_-_150578103	1.048		TM4SF1	transmembrane 4 L six family member 1
chr2_+_211166323	1.043	NM_001122634	CPS1	carbamoyl-phosphate synthase 1, mitochondrial
chr1_+_112740378	1.043
chr2_+_99163968	1.035	NM_145212	MRPL30	mitochondrial ribosomal protein L30
chr2_-_188086612	1.032		TFPI	tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
chr5_+_76150588	1.031	NM_005242	F2RL1	coagulation factor II (thrombin) receptor-like 1
chr5_+_176449156	1.011	NM_022963	FGFR4	fibroblast growth factor receptor 4
chr1_+_165565006	1.001		POU2F1	POU class 2 homeobox 1
chr11_+_69165159	0.998		CCND1	cyclin D1
chr6_-_47362102	0.983		TNFRSF21	tumor necrosis factor receptor superfamily, member 21
chr3_+_12367993	0.982	NM_015869	PPARG	peroxisome proliferator-activated receptor gamma
chr10_-_73518772	0.970	NM_001134434 NM_014767	SPOCK2	sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2
chr4_+_71096830	0.961	NM_017855	ODAM	odontogenic, ameloblast asssociated
chr10_+_123913094	0.948	NM_006997 NM_206860	TACC2	transforming, acidic coiled-coil containing protein 2
chr12_-_14887648	0.930	NM_021071	ART4	ADP-ribosyltransferase 4 (Dombrock blood group)
chr1_-_150148608	0.857	NM_053055	THEM4	thioesterase superfamily member 4
chr2_-_96769526	0.850	NM_001142292 NM_030805	LMAN2L	lectin, mannose-binding 2-like
chr9_-_103185621	0.848	NM_001127610	BAAT	bile acid CoA: amino acid N-acyltransferase (glycine N-choloyltransferase)
chr4_+_184257337	0.813	NM_024949	WWC2	WW and C2 domain containing 2
chr16_-_21221872	0.800	NM_001014444 NM_001888	CRYM	crystallin, mu
chr17_-_76720342	0.772		AATK	apoptosis-associated tyrosine kinase
chr4_+_9094611	0.765	NM_001040071	LOC650293	seven transmembrane helix receptor
chr11_-_35398077	0.765	NM_001195728	SLC1A2	solute carrier family 1 (glial high affinity glutamate transporter), member 2
chr11_+_20001130	0.752	NM_001111019	NAV2	neuron navigator 2
chr3_-_172227461	0.751	NM_000340	SLC2A2	solute carrier family 2 (facilitated glucose transporter), member 2
chr3_-_56784634	0.748	NM_001128616	ARHGEF3	Rho guanine nucleotide exchange factor (GEF) 3
chr6_+_64344307	0.740		PTP4A1	protein tyrosine phosphatase type IVA, member 1
chr7_+_47661366	0.735	NM_001123065	C7orf65	chromosome 7 open reading frame 65
chr10_-_116408046	0.732	NM_002313	ABLIM1	actin binding LIM protein 1
chr1_-_180627934	0.729	NM_001033044 NM_002065	GLUL	glutamate-ammonia ligase
chr4_+_187424336	0.721		F11	coagulation factor XI
chr16_+_14938800	0.705	NM_006985	NPIP	nuclear pore complex interacting protein
chr3_+_46594079	0.705	NM_003212	TDGF1	teratocarcinoma-derived growth factor 1
chr4_+_187424111	0.689	NM_000128	F11	coagulation factor XI
chr1_+_57093030	0.687	NM_000562	C8A	complement component 8, alpha polypeptide
chr3_-_9895633	0.684	NM_022094	CIDEC	cell death-inducing DFFA-like effector c
chr11_+_69165065	0.677		CCND1	cyclin D1
chr4_-_186815116	0.672	NM_001145674 NM_001145675	SORBS2	sorbin and SH3 domain containing 2
chr12_+_102859354	0.653		HSP90B1	heat shock protein 90kDa beta (Grp94), member 1
chr1_-_149214063	0.641	NM_022075 NM_181746	LASS2	LAG1 homolog, ceramide synthase 2
chr4_-_88076328	0.630
chr1_-_158759606	0.626	NM_001184714 NM_001184715 NM_001184716 NM_052931	SLAMF6	SLAM family member 6
chr7_-_55897938	0.618	NM_207366	SEPT14	septin 14
chr7_+_37689903	0.601
chr6_+_64414389	0.589	NM_015153	PHF3	PHD finger protein 3
chrX_+_70255128	0.582	NM_005120	MED12	mediator complex subunit 12
chr14_+_38719462	0.574		PNN	pinin, desmosome associated protein
chr14_+_38720085	0.573		PNN	pinin, desmosome associated protein
chr14_-_94677807	0.569	NM_030621	DICER1	dicer 1, ribonuclease type III
chr7_+_1092968	0.568	NM_001039966 NM_001505	GPER	G protein-coupled estrogen receptor 1
chr4_-_186970366	0.565	NM_003603 NM_001145670	SORBS2	sorbin and SH3 domain containing 2
chr10_+_123912930	0.555		TACC2	transforming, acidic coiled-coil containing protein 2
chr14_+_22859236	0.549	NM_004643	PABPN1	poly(A) binding protein, nuclear 1
chr7_-_29152597	0.530	NM_019029 NM_031311	CPVL	carboxypeptidase, vitellogenic-like
chr10_+_101532450	0.516	NM_000392	ABCC2	ATP-binding cassette, sub-family C (CFTR/MRP), member 2
chr2_+_99164064	0.509		MRPL30	mitochondrial ribosomal protein L30
chrY_-_2715478	0.509	NM_003140	SRY	sex determining region Y
chr2_-_200038055	0.507	NM_001172517	SATB2	SATB homeobox 2
chr6_+_131936057	0.505	NM_000045	ARG1	arginase, liver
chr10_-_29963906	0.499	NM_021738	SVIL	supervillin
chr2_-_188127294	0.496		TFPI	tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
chr6_+_31623370	0.487		NFKBIL1	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1
chr2_-_20390601	0.484	NM_015317	PUM2	pumilio homolog 2 (Drosophila)
chr16_-_21344158	0.480	NM_130464	NPIPL3	nuclear pore complex interacting protein-like 3
chr7_-_1562272	0.479	NM_001097620	TMEM184A	transmembrane protein 184A
chr15_-_74941339	0.475	NM_001145923	SCAPER	S-phase cyclin A-associated protein in the ER
chr9_-_36365965	0.475		RNF38	ring finger protein 38
chr20_-_45360903	0.473		ZMYND8	zinc finger, MYND-type containing 8
chr1_+_218930542	0.471		C1orf115	chromosome 1 open reading frame 115
chrX_+_100361588	0.460	NM_001171184 NM_001939	DRP2	dystrophin related protein 2
chr20_+_30161173	0.457		TM9SF4	transmembrane 9 superfamily protein member 4
chr1_-_92144146	0.454	NM_001195684	TGFBR3	transforming growth factor, beta receptor III
chr8_+_142501188	0.452	NM_007079 NM_032611	PTP4A3	protein tyrosine phosphatase type IVA, member 3
chr22_+_34025267	0.446	NM_001135729	TOM1	target of myb1 (chicken)
chr19_-_62370667	0.445	NM_001012729	DUXA	double homeobox A
chr4_-_17415918	0.433		DCAF16	DDB1 and CUL4 associated factor 16
chr5_+_76150637	0.430		F2RL1	coagulation factor II (thrombin) receptor-like 1
chr9_-_21340885	0.425	NM_021002	IFNA6	interferon, alpha 6
chr9_-_111230926	0.422	NM_001145371 NM_001145372	PTPN3	protein tyrosine phosphatase, non-receptor type 3
chr1_+_81544432	0.417		LPHN2	latrophilin 2
chr3_-_79899748	0.415	NM_002941	ROBO1	roundabout, axon guidance receptor, homolog 1 (Drosophila)
chr19_-_5789740	0.411		FUT6	fucosyltransferase 6 (alpha (1,3) fucosyltransferase)
chr3_+_157491469	0.406	NM_172159	KCNAB1	potassium voltage-gated channel, shaker-related subfamily, beta member 1
chr9_+_96561750	0.403	NM_001193329	C9orf3	chromosome 9 open reading frame 3
chr4_+_154397975	0.401		TRIM2	tripartite motif containing 2
chr10_-_11614279	0.401	NM_001080491	USP6NL	USP6 N-terminal like
chr3_+_101720753	0.394		TMEM45A	transmembrane protein 45A
chr7_-_87180499	0.390	NM_000927	ABCB1	ATP-binding cassette, sub-family B (MDR/TAP), member 1
chr10_+_5478521	0.385	NM_005863	NET1	neuroepithelial cell transforming 1
chr3_-_195553297	0.376	NM_001080513	CPN2	carboxypeptidase N, polypeptide 2
chr3_-_173723754	0.375	NM_001190943 NM_001190942 NM_003810	TNFSF10	tumor necrosis factor (ligand) superfamily, member 10
chr12_-_368689	0.374	NM_001042603	KDM5A	lysine (K)-specific demethylase 5A
chr9_+_96528814	0.373		C9orf3	chromosome 9 open reading frame 3
chr21_-_26175068	0.372		APP	amyloid beta (A4) precursor protein
chr17_-_24425342	0.371		TIAF1	TGFB1-induced anti-apoptotic factor 1
chr6_+_167445284	0.368	NM_004367	CCR6	chemokine (C-C motif) receptor 6
chr12_-_6354650	0.365	NM_001159576	SCNN1A	sodium channel, nonvoltage-gated 1 alpha
chr3_+_149930656	0.352	NM_032049	AGTR1	angiotensin II receptor, type 1
chr15_-_81271859	0.347	NM_001007122	FSD2	fibronectin type III and SPRY domain containing 2
chr12_+_132268067	0.336	NM_001165887 NM_003415 NM_152943	ZNF268	zinc finger protein 268
chr3_-_47909001	0.331		MAP4	microtubule-associated protein 4
chr14_-_94669547	0.331	NM_001195573	DICER1	dicer 1, ribonuclease type III
chr18_-_59462469	0.326	NM_002974	SERPINB4	serpin peptidase inhibitor, clade B (ovalbumin), member 4
chr18_+_44319365	0.325	NM_001142397 NM_014772	CTIF	CBP80/20-dependent translation initiation factor
chr6_+_10693964	0.321	NM_145655	GCNT2	glucosaminyl (N-acetyl) transferase 2, I-branching enzyme (I blood group)
chr2_-_43919392	0.320	NM_022436	ABCG5	ATP-binding cassette, sub-family G (WHITE), member 5
chr16_+_2593351	0.319		LOC652276	hypothetical LOC652276
chr8_-_17599438	0.307	NM_020749	MTUS1	microtubule associated tumor suppressor 1
chr3_-_180452338	0.300	NM_171830	KCNMB3	potassium large conductance calcium-activated channel, subfamily M beta member 3
chr22_+_16423147	0.300	NM_031481	SLC25A18	solute carrier family 25 (mitochondrial carrier), member 18
chr9_+_132579088	0.298	NM_007313	ABL1	c-abl oncogene 1, non-receptor tyrosine kinase
chr10_-_97190885	0.295	NM_001034954 NM_001034955 NM_001034956 NM_001034957 NM_006434	SORBS1	sorbin and SH3 domain containing 1
chr8_+_92184022	0.293	NM_001129890	LRRC69	leucine rich repeat containing 69
chr9_+_79158164	0.293		VPS13A	vacuolar protein sorting 13 homolog A (S. cerevisiae)
chr2_-_20375497	0.287		PUM2	pumilio homolog 2 (Drosophila)
chr2_+_204509698	0.287	NM_012092	ICOS	inducible T-cell co-stimulator
chr10_-_42183441	0.282		LOC283027	hypothetical protein LOC283027
chr12_+_63090008	0.281		XPOT	exportin, tRNA (nuclear export receptor for tRNAs)
chr20_-_51633042	0.279	NM_006526	ZNF217	zinc finger protein 217
chr16_+_82540172	0.279	NM_013370 NM_182980	OSGIN1	oxidative stress induced growth inhibitor 1
chr2_-_218865451	0.275	NM_022152	TMBIM1	transmembrane BAX inhibitor motif containing 1
chr11_-_82289006	0.274	NM_005040 NM_199418	PRCP	prolylcarboxypeptidase (angiotensinase C)
chr1_+_28637247	0.272	NM_023923	PHACTR4	phosphatase and actin regulator 4
chr20_+_56903595	0.266		GNAS	GNAS complex locus
chr1_+_144149794	0.265	NM_006472	TXNIP	thioredoxin interacting protein
chr15_+_57691272	0.264	NM_004751	GCNT3	glucosaminyl (N-acetyl) transferase 3, mucin type
chr3_+_63859114	0.260	NM_001177387	ATXN7	ataxin 7
chr14_+_38804226	0.256	NM_203354	CTAGE5	CTAGE family, member 5
chr19_+_21056792	0.248	NM_182515	ZNF714	zinc finger protein 714
chr1_+_67404756	0.248	NM_144701	IL23R	interleukin 23 receptor

Nothing significant found in process category.

Nothing significant found in compartment category.

Gene overrepresentation in function category:

enrichment	p-value	GO term	description
38.40	5.47e-03	GO:0047115	trans-1,2-dihydrobenzene-1,2-diol dehydrogenase activity
28.80	2.15e-02	GO:0047023	androsterone dehydrogenase activity
3.59	2.21e-02	GO:0001871	pattern binding
3.59	2.21e-02	GO:0030247	polysaccharide binding